Type 1 Diabetes

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Chapter 5 Microvascular complications

David Levy

  • • Hyperglycaemia damages the microvasculature through several mechanisms; strict control of hyperglycaemia remains overwhelmingly the most important factor in preventing and reversing microvascular complications in Type 1 diabetes.
  • • End-stage microvascular complications (blindness, end-stage renal failure, amputations for neuropathic foot complications) are probably becoming less common; no single responsible factor can be identified.
  • • The Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications follow-up (1982–2006) confirmed dramatic and long-lasting benefits of intensive therapy on microvascular complications (40–60% risk reduction) with A1C consistently maintained at ∼7% for ∼7 yrs.






DOI: 10.1093/med/9780199553211.003.0005

This highly practical volume in the Oxford Diabetes Library emphasises both the unique nature of Type 1 diabetes and its fundamental differences from Type 2 diabetes (at least in its "classic" form), and also draws together the common threads of management. It will be relevant to all advanced practitioners in primary and secondary care.

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Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work.

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